Patrick Reed, the defending champions, is a long way down the bookies lists after a difficult start to 2019.
He handed his Green Jacket back after hosting the Champions’ dinner but has stressed he is desperate to win another this year.
Rory McIlroy is the big favourite after the win at the Players Championship and is hoping to finally complete the Grand Slam with what would be his fifth Major victory.
Other contenders stretch from anywhere from Tiger Woods and Dustin Johnson to Francesco Molinari and Tommy Fleetwood.
However it is generally a lottery to pick a winner with the last four champions all bagging the first Major in the process.
Bubba Watson in 2014 won his second after winning his first here two years before, while Adam Scott, the year in between also picked up his first.
So that could set the weekend up for Fleetwood, looking to break his duck in America, or someone like a Bryson DeChambeau.
CURRENT MASTERS 2019 LEADERBOARD
Jordan Spieth is another man who likes the walk around these greens and despite a tough few months should not be underestimated.
Brooks Koepka currently holds two of the four Majors and is looking for his fourth after defending the US Open last year.
However his weight loss and rustiness have seem him drop down the pecking order.
Justin Rose starts the tournament as world No 1 looking to add to his solitary success at the US Open in 2013.
And the Englishman hopes he can justify his position at the top of the sport.
Rose, who finished T2 in 2015 and 2017 said: “I would take four. That would be awesome. I’d just love to say the word ‘multiple’.
“As long as it’s one of each,” he added, referring to The Open and US PGA Championship.
“I’ve seen some guys go through a career and not be able to get that elusive first major – and no doubt it’s a hole in any career – but I’d love to use the word ‘multiple’.”
“I have won as world number one, in San Diego in January, which was important for me,” said Rose.
“But clearly to win a major as world number one would be even more fantastic.
“I believe I can do it. But until you’ve won a major, or an Olympic gold medal, sometimes those achievements seem insurmountable.
“Should I go through another dip in form, I’ll always believe those results are still possible.”
Fleetwood, who missed the cut two years ago and then T17th last year thinks he comfortable enough with the course to launch an assault.
He said: “Year one there was so much to take in. Year two you’re more comfortable with it and, while I’m not at [1992 champion and veteran of 33 Masters] Fred Couples’ stage, I’m getting a better understanding and feeling of the tournament and the course.
“There are so many options, particularly hitting into greens, chipping around the greens and putting. I don’t think you can ever learn enough.”