Pep Guardiola’s City have already secured the League Cup and know they will retain their Premier League title if they win every game between now and the end of the season.
They also face Tottenham in the quarter-final of the Champions League before a potential semi-final with Liverpool or Porto.
Meanwhile, Chris Hughton’s Seagulls are in the last four of the Cup for the first time since 1983.
Here, Express Sport explains exactly how you can watch the action unfold.
What TV channel is Manchester City vs Brighton on?
BBC 1 will be showing the game with the build-up starting at 5.10pm.
Kick-off is set for 5.30pm.
Extra-time and penalties will be required if the match finishes as a draw
How can I stream the game online?
The game can be streamed via the BBC iPlayer on a variety of devices such as laptop, tablet and smartphone.
What the managers have said
Guardiola has won every domestic title on offer – except the FA Cup – and says he is desperate to win a competition he grew up watching.
City have not won it since 2011 and the boss said: “When I was young you saw the final of the FA Cup more than a Premier League game.
“The tradition, the fans, the managers – I cannot deny how nice it would be for me personally.
“The club has won it five times and we want another one, so we will try.”
Hughton admits his side go into the game as huge underdogs and favours a cautious approach against their free-scoring opponents.
“I think it’s foolish to go toe to toe,” he said.
“I’m certainly not embarrassed to say that you have to be able to try and contain them.
“They have too many options if you feel that you can take the game to them. They have so many strategies that can open you up.
“The last thing you need is to go into a game like this and you’re very quickly out of the game.”
When is the other semi-final?
Watford take on Wolves in the second semi-final at Wembley at 4pm tomorrow.
The final will take place on May 18.