Barcelona beat Atletico Madrid 2-0 on Saturday night, with Messi and Luis Suarez both scoring.
Diego Costa was sent off in the first half, handing Messi and co a crucial advantage.
Barcelona now boast an 11-point lead at the top of La Liga with seven games remaining.
Messi now has 43 goals in all competitions under Ernesto Valverde following his strike against Atletico Madrid.
The Argentina international sold Jan Oblak, leaving the Atletico star helpless at the Nou Camp.
Messi has dominated in La Liga this season following Cristiano Ronaldo’s departure from Real Madrid to Juventus.
And fans slammed Ronaldo following Messi’s goal, claiming the Barcelona star is the best to ever play the game.
One fan said: “Messi is the best in the world don’t even compare him to ronaldo.”
Another added: “Is my man Cristiano Ronaldo watching the match now? Messi!!!!!”
“If you think ronaldo is better than messi you just don’t know anything at all about football,” a fellow fan said.
Another fan added: “Messi!!!!! Messi!!!! Messi!!! Take a bow!!!”
“Messi is the goat,” one Barcelona fan simply put.
“Oh Messi stop it,” another added, followed by flame emojis.
A fellow Barcelona fan said: “Messi is my God.”
“Toooooooo easy for Messi,” said another supporter.
Ronaldo has impressed at Juventus after quitting Real Madrid last summer.
The Portugal star has netted 24 goals in all competitions for the Italian giants.