A large stack of mixed recyclables are alight on Neasden Lane.
The Brigade was called at 2.10am this morning.
Fire crews from Willesden, Park Royal, Wembley, Paddington, Northolt and West Hampstead fire stations are in attendance.
The cause of the fire is not known at this stage.
Jonathan Smith, Assistant Commissioner for Control and Mobilising with London Fire Brigade has asked members of the public to avoid the area.
He tweeted: “Currently dealing with a significant fire on Neasden Lane, NW10. @LondonFire crews are working hard in difficult conditions to bring the situation under control. Please avoid the area. #Neasden”
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